A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication
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چکیده
منابع مشابه
A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication.
The timing of DNA replication in the Xq27 portion of the human X chromosome was studied in cells derived from normal and fragile X males to further characterize the replication delay on fragile X chromosomes. By examining a number of sequence-tagged sites (STSs) that span several megabases of Xq27, we found this portion of the normal active X chromosome to be composed of two large zones with di...
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A controversy exists as to whether the human X chromosomes, both normal and abnormal, replicating late in the period of DNA synthesis (S) are also late to start replication at the beginning of S. Petersen (7), Cave (3), Ockey et al. (6), and Priest et al. (8) found evidence for late onset of X chromosome replication. However, Mukherjee and Sinha (5) and Bianchi and de Bianchi (1) did not confir...
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Chromosome analysis, after bromodeoxyuridine incorporation and a sequential Leishman acridine orange staining method previously described, was used to assess the percentage of early or active fragile Xs compared with the overall total in informative cells in 13 heterozygous females. The percentage thus obtained was then used to calculate the percentage of early or active fragile X that would be...
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It is now well recognised that the fragile X chromosome anomaly is associated with certain cases of X linked mental retardation.'-3 The fragile site is usually seen as an isochromatid gap at the interface of the long arm bands Xq27 and Xq28. However, we have observed that the fragile X is also frequently manifested as a deleted X chromosome with loss of the distal long arm band, q28 (figure). T...
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X chromosome inactivation has been hypothesised to play a role in the aetiology and clinical expression of the fragile X syndrome. The identification of the FMR1 gene involved in fragile X syndrome allows testing of the assumption that the fragile X locus is normally subject to X inactivation. We studied the expression of the FMR1 gene from inactive X chromosomes by reverse transcription of RNA...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.9.4587